HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloroimidazo[1,2-b]pyridazine-3-carbaldehyde → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(4,6-difluoro-1-methyl-1H-indazol-5-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloroimidazo[1,2-b]pyridazine-3-carbaldehyde | HCID 11446702 | — |
| Reactant | 4,6-Difluoro-1-methyl-1H-indazole | HCID 57917479 | — |
| Reactant | 1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-1-(4,6-difluoro-1-methyl-1H-indazol-5-yl)-ethanol | HCID 58147529 | — |
| Product | (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(4,6-difluoro-1-methyl-1H-indazol-5-yl)methanol | HCID 58190595 | 41% |
Reaction Steps
The title compound as a yellow solid (60 mg, 41%) was synthesized from (intermediate P) (70 mg, 0.416 mmol) and 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde (intermediate N) (76 mg, 0.416 mmol) using the same procedure as described in the synthesis of compound 51.1. 1H-NMR (400 MHz, MeOH-d4) δ ppm 8.08 (s, 1H), 8.03 (d, 1H), 7.85 (s, 1H), 7.26 (q, 2H), 6.76 (s, 1H), 4.03 (s, 3H). LCMS (method B): [MH]+=349.9, tR=2.12 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507676B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-3d45097b74314ed183a2e7a0970aa224 |
| Source note | uspto-grants-2013_08 |