HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(3-Bromo-6-quinolinyl)methyl]-1H-isoindole-1,3(2H)-dione → HCID 58190486, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(3-Bromo-6-quinolinyl)methyl]-1H-isoindole-1,3(2H)-dione | HCID 58190543 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Product | HCID 58190486 | HCID 58190486 | — |
Reaction Steps
A solution of 2-(3-Bromo-quinolin-6-ylmethyl)-isoindole-1,3-dione (635 g, 1.73 mmol) in 15 mL of methanol and 1 mL of hydrazine monohydrate was heated at 80° C. for 2 h. After cooling, the solvent was removed in vacuo and the residue was purified by flash chromatography on silica gel eluting with EtOAc/methanol gradient to afford the title compound. LCMS (method A): [MH]+=237/239, tR=2.795 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507676B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-35bd4764d4e04b8692688c1c445ea627 |
| Source note | uspto-grants-2013_08 |