N-(4-Formyl-1,3-thiazol-2-YL)acetamide → 4-[2-[2-(Acetylamino)-4-thiazolyl]ethenyl]-2,3-difluorobenzoic acid

Participants

Reaction Steps

N-(4-Formyl-1,3-thiazol-2-yl)acetamide (1.071 g, 6.292 mmol) and (4-carboxy-2,3-difluorobenzyl)(triphenyl)phosphoniumbromide (3.227 g, 6.287 mmol) were condensed by a method similar to that of Production Example 4, step 3, to give 4-{2-[2-(acetylamino)-1,3-thiazol-4-yl]vinyl}-2,3-difluorobenzoic acid (1.550 g, 4.778 mmol, yield 76.0%) as a yellow solid.

Provenance & Evidence