Pyridine → HCID 67958066, compound

Participants

Reaction Steps

A mixture of 6-(ethylamino)-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide (90 mg, 0.151 mmol), pyridine (5.0 mL), DMAP (18.46 mg, 0.151 mmol) and methanesulfonyl chloride (0.018 mL, 0.227 mmol) was stirred at room temperature overnight. The reaction mixture was diluted with water and extracted with EtOAc (20 ml×2). The combined organic extracts were washed with brine, dried over Na2SO4 and concentrated. The crude product was purified by prep HPLC.

Provenance & Evidence