HCID 67151276, compound → 1301214-66-3

HRID 1892580Notes

Reaction equation

HRID 1892580 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]([N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])=[N:8][CH:9]=1)([O-])=O.[H][H]>[Pd].C(O)(=O)C>[N:12]1([C:10]([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)=[O:11])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 67151276HCID 67151276, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 671512211301214-66-3

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

Crude 5-nitro-2-(piperidin-1-ylcarbonyl)pyridine was reduced by hydrogen under atmospheric pressure in the presence of 10% palladium on carbon (4 g) in acetic acid (500 mL). The catalyst was separated by filtration and the solvent evaporated in vacuum to give crude 6-(piperidin-1-ylcarbonyl)pyridin-3-amine, which was used for the next stage without additional purification.

Workup

  1. customThe catalyst was separated by filtration
  2. customthe solvent evaporated in vacuum

Sources & evidence

ORD record
ord-233c945fee3d4cc4b95d899753a5ab68
Source dataset
uspto-grants-2013_08
Patent number
US08507681B2

Reaction notes

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