P-Anisidine → HCID 68156787, compound

HRID 1892685Notes

Reaction equation

HRID 1892685 reaction equation
C[O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([N+:19]([O-])=O)=[C:15]([CH:18]=1)[CH:16]=O>>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]2[C:15](=[CH:16][N:7]([C:6]3[CH:8]=[CH:9][C:3]([OH:2])=[CH:4][CH:5]=3)[N:19]=2)[CH:18]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 811235-Chloro-2-nitrobenzaldehyde

Product 1

HCID 68156787HCID 68156787, compound

Procedure

4-(5-chloro-2H-indazol-2-yl)phenol was prepared using a method analogous to that described for Intermediate (Q10), starting from 4-methoxyaniline and 5-chloro-2-nitrobenzaldehyde. Yellow solid. 1HNMR (400 MHz Methanol-d4) δ 8.60 (d, J=1.6 Hz, 1H), 7.71-7.75 (m, 3H), 7.65 (d, J=9.2 Hz, 1H), 7.27 (dd, J=9.2, 2.0 Hz, 1H), 6.95 (d, J=8.8 Hz, 2H).

Sources & evidence

ORD record
ord-900ad9c79dbd4e1db3e0c1112b2e73ee
Source dataset
uspto-grants-2013_08
Patent number
US08507533B2

Reaction notes

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