benzyl 5-tert-butyl-2-(5-oxo-1,4-diazepane-1-carbonyl)-1H-pyrrol-3-ylcarbamate → 1-(4-amino-2-tert-butyl-1H-pyrrole-5-carbonyl)-1,4-diazepan-5-one

Participants

Reaction Steps

A mixture of the previously benzyl 5-tert-butyl-2-(5-oxo-1,4-diazepane-1-carbonyl)-1H-pyrrol-3-ylcarbamate (40 mg, 0.097 mmol), Pd on charcoal (10% w/w, 20 mg) and methanol (2 mL) was shaken in a Parr shaker under hydrogen (50 psi) for 18 hours. The reaction mixture was filtered through celite and the residue was concentrated under vacuum to afford 20 mg of the desired 1-(4-amino-2-tert-butyl-1H-pyrrole-5-carbonyl)-1,4-diazepan-5-one as a clear oil.

Provenance & Evidence