HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-methyl-5-nitropyridine → 5-methyl-6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-methyl-5-nitropyridine | HCID 89648 | — |
| Reactant | 4-(Trifluoromethyl)-1H-pyrazole | HCID 12777795 | — |
| Product | 5-methyl-6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-amine | HCID 64173725 | — |
Reaction Steps
The title compound was prepared by a method analogous to that described for Intermediate (6) using 4-trifluoromethyl-1H-pyrazole and 2-chloro-3-methyl-5-nitro-pyridine. 1H NMR (400 MHz, CDCl3, δ): 8.21 (s, 1H), 7.85 (s, 1H), 7.75 (d, J=2.4 Hz, 1H), 6.93 (d, J=2.4 Hz, 1H), 3.85 (s, 2H), 2.32 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08507533B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-c468778f0b5842ecb91cc8a6c13a1179 |
| Source note | uspto-grants-2013_08 |