Nitric Acid → 4'-Bromo-3'-nitropropiophenone

HRID 1892819Notes

Reaction equation

HRID 1892819 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[N+:12]([O-])([OH:14])=[O:13]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:6][C:7]=1[N+:12]([O-:14])=[O:13]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 66312p-Bromopropiophenone

Product 1

HCID 33626924'-Bromo-3'-nitropropiophenone

Procedure

To fuming nitric acid (200 ml), 1-(4-bromophenyl)-1-propanone (40 g) was added while keeping the inside temperature of the mixture at 5 to 10° C. The reaction solution was stirred at that temperature for 30 minutes and then poured into ice. The precipitate was collected by filtration, washed with distilled water, and recrystallized from methanol to obtain the title compound (18 g).

Workup

  1. customat 5 to 10° C
  2. additionpoured into ice
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with distilled water
  5. customrecrystallized from methanol

Sources & evidence

ORD record
ord-9cd7070423cc47d682faf66f1a4847d8
Source dataset
uspto-grants-2013_08
Patent number
US08507714B2

Reaction notes

Loading…