HCID 57670971, compound → HCID 57671063, compound

HRID 1892836Notes

Reaction equation

HRID 1892836 reaction equation
[CH3:1][O:2][C:3]1[CH:28]=[CH:27][C:26]([O:29]COC)=[CH:25][C:4]=1/[CH:5]=[C:6]1/[C:7](=[O:24])[N:8]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:9][C:10](=[O:13])[NH:11][CH2:12]/1.[OH:33][C:34]1[CH:59]=[CH:58][C:57]([CH3:60])=[CH:56][C:35]=1/[CH:36]=[C:37]1/[C:38](=[O:55])[N:39]([S:45]([C:48]2[CH:53]=[CH:52][C:51]([Cl:54])=[CH:50][CH:49]=2)(=[O:47])=[O:46])[CH2:40][C:41](=[O:44])[NH:42][CH2:43]/1>>[CH3:1][O:2][CH2:3][O:33][C:34]1[CH:59]=[CH:58][C:57]([CH3:60])=[CH:56][C:35]=1/[CH:36]=[C:37]1/[C:38](=[O:55])[N:39]([S:45]([C:48]2[CH:49]=[CH:50][C:51]([Cl:54])=[CH:52][CH:53]=2)(=[O:46])=[O:47])[CH2:40][C:41](=[O:44])[NH:42][CH2:43]/1.[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([S:14]([N:8]2[C:7](=[O:24])/[C:6](=[CH:5]/[C:4]3[CH:25]=[C:26]([OH:29])[CH:27]=[CH:28][C:3]=3[O:2][CH3:1])/[CH2:12][NH:11][C:10](=[O:13])[CH2:9]2)(=[O:15])=[O:16])=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 57670971HCID 57670971, compoundHCID 66934890HCID 66934890, compound

Product 2

HCID 57671063HCID 57671063, compoundHCID 66935148HCID 66935148, compound

Procedure

(6E)-6-[2-methoxy-5-(methoxymethoxy)benzylidene]-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepan-2,5-dione, synthesized by using, instead of the starting material of Reference Example 117, that is, the compound S6, the compound S22 for the similar procedure as in Reference Example 117, Reference Example 122, and Example 1, was used instead of the starting material compound of Example 193, that is, (6E)-6-[2-(methoxymethoxy)-5-methylbenzylidene]-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepan-2,5-dione, for the similar procedure as in Example 193 to obtain the title compound.

Sources & evidence

ORD record
ord-396b389f663548088cf0cbd9bc63195a
Source dataset
uspto-grants-2013_08
Patent number
US08507714B2

Reaction notes

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