Methylamine → 6-(5-Chloro-2-methoxybenzyl)-n-{(1r)-1-[(methylamino)carbonyl]propyl}-3,7-dioxo-1,4-diazepan-1-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Methylamine	HCID 6329	—
Reactant	Glycine tert-butyl ester hydrochloride	HCID 2725036	—
Reactant	Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate	HCID 76588771	—
Product	6-(5-Chloro-2-methoxybenzyl)-n-{(1r)-1-[(methylamino)carbonyl]propyl}-3,7-dioxo-1,4-diazepan-1-carboxamide	HCID 57671011	—

Reaction Steps

Instead of the starting material compound of Example 220, that is, glycine tert-butyl ester hydrochloride, a methylamine 30% ethanol solution was used for the similar procedure as in Example 220 to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08507714B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-0a1dac9988354065bcee3568e9ddac4d
Source note	uspto-grants-2013_08