Glycine tert-butyl ester hydrochloride → HCID 57671099, compound

HRID 1892850Notes

Reaction equation

HRID 1892850 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.[C:38](OC(=O)CN)(C)(C)C.Cl.C(OC(=O)[C@H](C)N)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:22][C@@H:23]([CH3:38])[C:24]([OH:26])=[O:25])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1

Participants

4

Reactant 3

HCID 2725036Glycine tert-butyl ester hydrochlorideHCID 11275390tert-Butyl alaninate hydrochlorideHCID 76588771Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate

Product 1

HCID 57671099HCID 57671099, compound

Procedure

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, L-alanine tert-butyl ester hydrochloride was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Sources & evidence

ORD record
ord-33a6af0db7b64bd68c2469a3834ed010
Source dataset
uspto-grants-2013_08
Patent number
US08507714B2

Reaction notes

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