Glycine tert-butyl ester hydrochloride → HCID 66934878, compound

HRID 1892855Notes

Reaction equation

HRID 1892855 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22][CH2:23]C(OC(C)(C)C)=O)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.C(OC(=O)CN)(C)(C)C.[NH2:47][C:48]1[CH:60]=[CH:59]C(N)=[CH:57][C:49]=1[C:50]([O:52]C(C)(C)C)=[O:51]>>[ClH:1].[NH2:47][C:48]1[CH:60]=[CH:59][C:23]([NH:22][C:20](=[O:21])[C@H:19]([NH:18][C:16]([N:13]2[C:14](=[O:15])[CH:8]([CH2:7][C:6]3[CH:34]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:35][CH3:36])[CH2:9][NH:10][C:11](=[O:33])[CH2:12]2)=[O:17])[CH2:31][CH3:32])=[CH:57][C:49]=1[C:50]([OH:52])=[O:51]

Participants

4

Reactant 3

HCID 2725036Glycine tert-butyl ester hydrochlorideHCID 20202630HCID 20202630, compoundHCID 76588771Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate

Product 1

HCID 66934878HCID 66934878, compound

Procedure

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, tert-butyl 2,5-diaminobenzoate was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Sources & evidence

ORD record
ord-0d75576f1c5f4df4961367c6c04b0bae
Source dataset
uspto-grants-2013_08
Patent number
US08507714B2

Reaction notes

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