HRID1892861

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67987

4-Fluoro-3-nitrobenzoic acid

C7H4FNO4

HCID7016560

4-nitro-1H-pyrrole-2-carboxylic Acid

C5H4N2O4

结构：CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1c[nH]c(C(=O)O)c1

HCID57671144

未命名化合物

PRODUCTS

生成物

结构：CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cc(C(=O)O)ccc1F

HCID57671002

未命名化合物

PROCEDURE

实验过程

Instead of the starting material compound of Example 262, that is, 4-nitropyrrole-2-carboxylic acid, 4-fluoro-3-nitrobenzoic acid was used for the similar procedure as in Example 262 to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a1467adc371741b0b23dd3ca35e6fd65
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08507714B2
来源说明: uspto-grants-2013_08

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20](NC2C=C(C(O)=O)NC=2)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.[N+](C1C=C(C(O)=O)NC=1)([O-])=O.[F:48][C:49]1[CH:57]=[CH:56][C:52]([C:53]([OH:55])=[O:54])=[CH:51][C:50]=1[N+:58]([O-])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:58][C:50]2[CH:51]=[C:52]([CH:56]=[CH:57][C:49]=2[F:48])[C:53]([OH:55])=[O:54])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1