Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | C28H45ClO2 | HCID 54236888 | — |
| Reactant | 6-Amino-1-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-hexan-1-one | HCID 131728207 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131728209 | HCID 131728209 | 187% |
Reaction Steps
Referring to scheme 2, compound 5 (13.3 g, 25 mmol) was dissolved in anhydrous dichloromethane (100 mL) and cooled to 0° C. To the solution were added triethylamine (7.5 g, 10 mL, 75 mmol) and cholesteryl chloroformate (11.24 g, 25 mmol) successively. The reaction temperature was brought to ambient temperature and stirred further for 2 h. The completion of the reaction was ascertained by TLC (10% MeOH/CHCl3). The reaction mixture was evaporated under the vacuum to afford the crude product. Compound 6 (22.1 g, 93%) was obtained as a white foamy solid after column chromatography over silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08507661B2 |
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| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-ecb9e0542f0849a09a1c595563264c37 |
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| Source note | uspto-grants-2013_08 |
|---|
