HRID1893161

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21885

2-Dimethylaminopyridine

C7H10N2

HCID70498

Phenyl thioxochloroformate

C7H5ClOS

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(n2cnc3c(N)ncnc32)C(O)C1OCc1ccccc1

HCID131730811

未命名化合物

PRODUCTS

生成物

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(n2cnc3c(N)ncnc32)C(OC(=S)Oc2ccccc2)C1OCc1ccccc1

HCID131730812

未命名化合物

收率 82%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A flask was charged with 2-(6-Amino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-ol, acetonitrile, dimethylamino pyridine (DMAP), and PhOCSCl. The reaction was stirred, extracted, and the solvent was evaporated to provide the titled compound in 82% yield.

WORKUP

后处理

extractionextracted
customthe solvent was evaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a0dcc95a44054643b866fc32b430e916
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08513214B2
来源说明: uspto-grants-2013_08

反应 SMILES

[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH:11]1[CH:15]([OH:16])[CH:14]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]([C:27]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[O:28][SiH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])([CH:25]=[CH2:26])[O:12]1.CN(C1C=CC=CN=1)C.[C:55]1([O:61][C:62](Cl)=[S:63])[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=1>C(#N)C>[C:55]1([O:61][C:62](=[S:63])[O:16][CH:15]2[CH:14]([O:17][CH2:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:13]([C:27]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[O:28][SiH2:29][C:30]([CH3:31])([CH3:32])[CH3:33])([CH:25]=[CH2:26])[O:12][CH:11]2[N:6]2[CH:5]=[N:4][C:3]3[C:7]2=[N:8][CH:9]=[N:10][C:2]=3[NH2:1])[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=1