Boron trifluoride etherate → HCID 12134925, compound

Participants

Reaction Steps

2-Phenoxy-3-(4-benzyloxyphenyl)-3-hydroxy-2-methyl-propionic acid ethyl ester (20.4 g, 50 mmol) in anhydrous CH2Cl2 (200 mL) was cooled to 0° C. and treated with BF3-Et2O (6.12 mL, 50 mmol) and triethylsilane (8.16 mL, 9.5 mmol). The mixture was stirred over night. Saturated aqueous Na2CO3 (75 mL) was added and the mixture was stirred vigorously. The solution was partitioned and the organic layer was washed twice with water and brine, dried over MgSO4 and concentrated in vacuo, then purified in silica to provide a colorless oil (9.9 g, 51%)

Provenance & Evidence