Phenol → HCID 59493234, compound

HRID 1893177Notes

Reaction equation

HRID 1893177 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl[C:11]1[N:16]=[C:15]([Cl:17])[CH:14]=[C:13]([Cl:18])[N:12]=1>O.CC(C)=O>[Cl:18][C:13]1[CH:14]=[C:15]([Cl:17])[N:16]=[C:11]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:12]=1

Participants

6

Reactant 3

HCID 996PhenolHCID 14798Sodium HydroxideHCID 773782,4,6-Trichloropyrimidine

Product 1

HCID 59493234HCID 59493234, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

Phenol (0.94 g, 10 mmol) and sodium hydroxide (0.44 g, 11 mmol) in water (20 ml) were added to 2,4,6-trichloropyrimidine (1.83 g, 10 mmol) in acetone (20 ml) at 0° C. The mixture was stirred over night. The precipitate then filtered through celite, then the most of the acetone was removed in vacuo. The resulting aqueous solution was extracted with ethyl acetate, dried over sodium sulfate, and concentrated in vacuo. The residue was purified in silica to provide a colorless oil.

Workup

  1. filtrationThe precipitate then filtered through celite
  2. customthe most of the acetone was removed in vacuo
  3. extractionThe resulting aqueous solution was extracted with ethyl acetate
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified in silica
  7. customto provide a colorless oil

Sources & evidence

ORD record
ord-e840c535b1234c909a9d0a230a742606
Source dataset
uspto-grants-2013_08
Patent number
US08513233B2

Reaction notes

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