Hydroxylamine → HCID 59271841, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl [1-cyano-4,4-dimethyl-5-(tetrahydro-2H-pyran-2-yloxy)pentyl]methylcarbamate (8.5 g, 23.98 mmol), in methanol (5 mL) was added 50% hydroxylamine (1.543 mL, 25.2 mmol). The mixture was heated to 60° C. for 3 hours (LC-MS indicates complete conversion) cooled and concentrated. Removal of excess hydroxylamine azeotropically with methanol gave tert-butyl [1-[(Z)-amino(hydroxyimino)methyl]-4,4-dimethyl-5-(tetrahydro-2H-pyran-2-yloxy)pentyl]methylcarbamate: MS (ES+): 388.26 (M+H).

Provenance & Evidence