Hydroxylamine → HCID 178494954, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl(5-{[tert-butyl(dimethyl)silyl]oxy}-1-cyano-4-methoxy-4-methylpentyl)methylcarbamate (4.37 kg, 10.91 mol) in MeOH (28 L) at 30° C. was added aqueous hydroxylamine (50% in water, 1.2 L, 19.63 mol). The resulting mixture was heated to 40° C. overnight, then cooled and concentrated in vacuo. The crude residue was dissolved in 1.5 L of toluene, concentrated under reduced pressure, and dried in vacuo. The crude material was used in the next step without further purification. LC-MS: 434.3.

Provenance & Evidence