Hydroxylamine → HCID 59271887, compound

Participants

Reaction Conditions

Reaction Steps

The tert-butyl (1-cyano-5-hydroxyhexyl)methylcarbamate (129 g) which contained an undetermined amount of t-butanol was dissolved in methanol (250 mL) and treated with 50% aqueous hydroxylamine (33 mL). The mixture was then heated to 60° C. for 3 hours. The reaction mixture was then cooled and the solvents removed in vacuo. The residue was azeotropically dried twice with toluene (200 mL each time) and dried in vacuo at 50° C. to give the product as a very thick clear oil which was contaminated by t-butanol: ES MS M+1=290.0.

Provenance & Evidence