Hydrochloric Acid → HCID 59271820, compound

Participants

Reaction Steps

To a solution of the methyl trans-rac-10-[(tert-butoxycarbonyl)(methyl)amino]-6-methyl-3-[(methylsulfonyl)oxy]-4-oxo-4,6,7,8,9,10-hexahydropyrimido [1,2-a]azepine-2-carboxylate (3.5 g) in dioxane (25 mL) at 0° C. was added 4M HCl in dioxane (25 mL). After stirring for 30 minutes the reaction mixture was allowed to warm to room temperature and stirred there for 4 hours. The solvent was stripped and the residue dissolved in water and treated with excess sodium carbonate. The resulting mixture was extracted with methylene chloride, then chloroform and dried over sodium sulfate. Filtration and concentration gave the amine as dark brown viscous oil.

Provenance & Evidence