Hydroxylamine → HCID 178465443, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl[(4S)-5-(benzyloxy)-1-cyano-4-methoxypentyl]ethylcarbamate (74 g, 197 mmol) in EtOH (1000 mL) was added TEA (54.8 mL, 393 mmol) and NH2OH (50% in water, 14.45 mL, 236 mmol). The resulting solution was stirred at 40° C. overnight and then concentrated in vacuo. The residue was dissolved in MeOH and the solvent was removed under reduced pressure (3×) to remove water. The crude residue was used in the next reaction without further purification. LC-MS: 410.5 (M+1).

Provenance & Evidence