Methanol → HCID 136085214, compound

Participants

Reaction Steps

To a solution of tert-butyl{(4S)-5-(benzyloxy)-1-[(hydroxyamino)(imino)methyl]-4-methoxypentyl}ethylcarbamate (72.6 g, 177 mmol) in MeOH (1773 ml) at 0° C. was added dimethyl acetylene dicarboxylate (26.3 mL, 213 mmol). The reaction mixture was stirred at ambient temperature overnight and then concentrated in vacuo. The residue was dissolved in toluene and concentrated in vacuo (3×) to remove MeOH. The crude product was used in the next reaction without purification. LC-MS: 553.5 (M+1).

Provenance & Evidence