Acetic Acid → HCID 136085211, compound

Participants

Reaction Steps

To a solution of methyl 2-{(4S)-5-(benzyloxy)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxypentyl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate (13 g, 25.02 mmol) in EtOAc (30 mL) and MeOH (30 mL) was added acetic acid (20 mL) and palladium on carbon (Degussa, 10% by mass, 13 g, 122 mmol). The reaction mixture was shaken on a Parr apparatus under hydrogen gas (50 psi) for 4 days and then filtrated through a pad of celite. The filter cake was washed with MeOH. The filtrate was concentrated in vacuo. The crude residue was used in the next reaction without further purification. LC-MS: 429.89 (M+1).

Provenance & Evidence