1,4-Dioxaspiro[4.5]decan-8-one → 8-(2,3-Dihydro-benzofuran-6-yl)-1,4-dioxa-spiro[4.5]decan-8-ol

HRID 1893222Notes

Reaction equation

HRID 1893222 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:5]2[CH2:6][CH2:7][O:8][C:4]=2[CH:3]=1.[O:11]1[C:15]2([CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1>>[O:8]1[C:4]2[CH:3]=[C:2]([C:18]3([OH:21])[CH2:19][CH2:20][C:15]4([O:14][CH2:13][CH2:12][O:11]4)[CH2:16][CH2:17]3)[CH:10]=[CH:9][C:5]=2[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 112526166-Bromo-2,3-dihydro-1-benzofuran

Product 1

HCID 595419478-(2,3-Dihydro-benzofuran-6-yl)-1,4-dioxa-spiro[4.5]decan-8-ol

Procedure

The title compound was prepared as a white solid from 6-bromo-2,3-dihydro-benzofuran (Milestone) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 1.

Sources & evidence

ORD record
ord-831290176a814ed28ff9fbbbfd81fc2b
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

Loading…