HCID 59541900, compound → HCID 59541955, compound

Participants

Reaction Steps

To a Parr hydrogenation flask was added a solution of 5-(4-oxo-cyclohex-1-enyl)-3H-benzooxazol-2-one (as prepared in the previous step, 180 mg, 0.79 mmol) in MeOH (10 mL) followed by 5% Pd/C (Aldrich, ˜100 mg). The reaction was charged with 40 psi H2 gas for 10 hours at room temperature. The catalyst was removed by passing the reaction solution through a pad of Celite. MeOH was added to washed the Celite column three times. The combined organic layers were concentrated in vacuo to give the title compound as a white solid.

Provenance & Evidence