HCID 11275622, compound → HCID 49763684, compound

HRID 1893232Notes

Reaction equation

HRID 1893232 reaction equation
O=[C:2]1[CH2:7][CH2:6][C:5]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[C:11]#[N:12])=[CH:4][CH2:3]1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)=[O:22])[CH2:17]1>>[C:11]([C:10]1[CH:9]=[C:8]([CH:5]2[CH2:6][CH2:7][CH:2]([N:16]3[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:33])[F:34])[CH:27]=4)=[O:22])[CH2:17]3)[CH2:3][CH2:4]2)[CH:15]=[CH:14][CH:13]=1)#[N:12]

Participants

3

Reactant 2

HCID 11275622HCID 11275622, compoundHCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide

Product 1

HCID 49763684HCID 49763684, compound

Procedure

The title compounds were prepared as white solids from hydrogenation of 3-(4-oxo-cyclohex-1-enyl)-benzonitrile (as prepared in the previous step) followed by reductive amination of the corresponding ketone with N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedures described in Step C of Example 5 and Step C of Example 4.

Workup

  1. customas prepared in the previous step)

Sources & evidence

ORD record
ord-661547d512914a6da7dbeaf03d30b68b
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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