HCID 22633623, compound → HCID 49763802, compound

HRID 1893235Notes

Reaction equation

HRID 1893235 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]2)[CH:6]=1)[CH3:2].[NH:19]1[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)=[O:25])[CH2:20]1>>[CH2:1]([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][CH:14]([N:19]3[CH2:22][CH:21]([NH:23][C:24](=[O:25])[CH2:26][NH:27][C:28](=[O:39])[C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:37])([F:38])[F:36])[CH:30]=4)[CH2:20]3)[CH2:13][CH2:12]2)[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 22633623HCID 22633623, compoundHCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide

Product 1

HCID 49763802HCID 49763802, compound

Procedure

The title compound was prepared as a white solid by the reductive amination of 3-(4-oxo-cyclohexyl)-benzoic acid ethyl ester (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.

Sources & evidence

ORD record
ord-4cde23b5517340a194318ba65be5d979
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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