HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxy-4-phenylcyclohexan-1-one → N-{[1-(4-Hydroxy-4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxy-4-phenylcyclohexan-1-one | HCID 583741 | — |
| Reactant | N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide | HCID 59361594 | — |
| Product | N-{[1-(4-Hydroxy-4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide | HCID 46927116 | — |
Reaction Steps
The title compound was prepared as a white solid by reductive amination of 4-hydroxy-4-phenyl-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513229B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-b31949d6ce89417094a2b164d4130274 |
| Source note | uspto-grants-2013_08 |