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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1893251Generated: November 3, 2026

4-Hydroxy-4-phenylcyclohexan-1-one → N-{[1-(4-Hydroxy-4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide

https://huagongshe.com/reaction/1893251

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Hydroxy-4-phenylcyclohexan-1-oneHCID 583741—
ReactantN-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59361594—
ProductN-{[1-(4-Hydroxy-4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamideHCID 46927116—

Reaction Steps

The title compound was prepared as a white solid by reductive amination of 4-hydroxy-4-phenyl-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08513229B2
Source datasetuspto-grants-2013_08
ORD IDord-b31949d6ce89417094a2b164d4130274
Source noteuspto-grants-2013_08