HCID 22924041, compound → HCID 49764318, compound

HRID 1893253Notes

Reaction equation

HRID 1893253 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]3([OH:18])[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.[NH:19]1[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)=[O:25])[CH2:20]1>>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([C:11]3([OH:18])[CH2:16][CH2:15][CH:14]([N:19]4[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]5[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:36])[F:37])[CH:30]=5)=[O:25])[CH2:20]4)[CH2:13][CH2:12]3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 22924041HCID 22924041, compoundHCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide

Product 1

HCID 49764318HCID 49764318, compound

Procedure

The title compound was prepared as a white solid by reductive amination of 4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-4-hydroxy-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.

Sources & evidence

ORD record
ord-c25dc05d84404ac1be5be2c5de6929d6
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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