N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49764320, compound

HRID 1893255Notes

Reaction equation

HRID 1893255 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([OH:17])[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[NH:3][CH:2]=1.[NH:18]1[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=2)=[O:24])[CH2:19]1>>[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([OH:17])[CH2:15][CH2:14][CH:13]([N:18]4[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]5[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[CH:29]=5)=[O:24])[CH2:19]4)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[NH:3][CH:2]=1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541896HCID 59541896, compound

Product 1

HCID 49764320HCID 49764320, compound

Procedure

The title compound was prepared as a white solid by reductive amination of 4-(3H-benzoimidazol-5-yl)-4-hydroxy-cyclohexanone (as prepared in Example 20, Step B) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.

Sources & evidence

ORD record
ord-756abadc98134b1395273c3437239c0b
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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