3-Bromoanisole → 8-(3-Methoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 1893258Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[CH:3]=1.[O:10]1[C:14]2([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]2)[O:13][CH2:12][CH2:11]1>>[CH3:9][O:8][C:4]1[CH:3]=[C:2]([C:17]2([OH:20])[CH2:18][CH2:19][C:14]3([O:13][CH2:12][CH2:11][O:10]3)[CH2:15][CH2:16]2)[CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 169713-Bromoanisole

HCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 231336898-(3-Methoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Procedure

The title compound was prepared as a white solid from 1-bromo-3-methoxy-benzene (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 1.

Sources & evidence

ORD record: ord-d575ed9a11f541978fb038093f13fbc8
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513229B2

Reaction notes

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