3-Aminoazetidine, 3-BOC protected → HCID 59541920, compound

HRID 1893260Notes

Reaction equation

HRID 1893260 reaction equation
[OH:1][C:2]1([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([S:15][CH3:16])[CH:10]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[C:17]([O:21][C:22](=[O:28])[NH:23][CH:24]1[CH2:27][NH:26][CH2:25]1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22](=[O:28])[NH:23][CH:24]1[CH2:27][N:26]([CH:5]2[CH2:6][CH2:7][C:2]([OH:1])([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([S:15][CH3:16])[CH:10]=3)[CH2:3][CH2:4]2)[CH2:25]1)([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 15194053-Aminoazetidine, 3-BOC protectedHCID 59541959HCID 59541959, compound

Product 1

HCID 59541920HCID 59541920, compound

Procedure

The title compound was prepared as a white solid from 4-hydroxy-4-(3-methylsulfanyl-phenyl)-cyclohexanone (as prepared in Example 14, Step B) and azetidin-3-yl-carbamic acid tert-butyl ester using the procedure described in Step D of Example 1.

Sources & evidence

ORD record
ord-a84b51ec891541ebaf02f93a1ceee57d
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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