3-Bromo-N,N-dimethylaniline → 8-(3-(Dimethylamino)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 1893261Notes

Reaction equation

HRID 1893261 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]([CH3:10])[CH3:9])[CH:3]=1.[O:11]1[C:15]2([CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1>>[CH3:9][N:8]([CH3:10])[C:4]1[CH:3]=[C:2]([C:18]2([OH:21])[CH2:19][CH2:20][C:15]3([O:14][CH2:13][CH2:12][O:11]3)[CH2:16][CH2:17]2)[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 1401023-Bromo-N,N-dimethylanilineHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 595419398-(3-(Dimethylamino)phenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Procedure

The title compound was prepared as a white solid from 1-bromo-3-dimethylamino-benzene (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 1.

Sources & evidence

ORD record
ord-0cac62e60dc9490e836c7342643a020f
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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