Tetrabutylammonium Fluoride → HCID 59541930, compound

Participants

Reaction Steps

4-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-cyclohex-3-enone (2.0 g, 6.62 mmol) in THF was treated with TBAF (1N in THF, 10 mL, 9.93 mmol) at room temperature. After 10 min., the solvent was removed and the residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered, and the filtrate concentrated in vacuo to give colorless oil, which was purified on a silica gel column by a CombiFlash® system using hexanes and ethyl acetate as eluent (from pure hexanes to pure ethyl acetate) to afford the title compound as a white solid.

Provenance & Evidence