N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49763095, compound

HRID 1893292Notes

Reaction equation

HRID 1893292 reaction equation
[OH:1][C:2]1([C:9]2[CH:20]=[CH:19][C:12]3[N:13]([CH3:18])[C:14](=[O:17])[N:15]([CH3:16])[C:11]=3[CH:10]=2)[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:21]1[CH2:24][CH:23]([NH:25][C:26]([CH2:28][NH:29][C:30](=[O:41])[C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:39])[F:38])[CH:32]=2)=[O:27])[CH2:22]1>>[CH3:18][N:13]1[C:12]2[CH:19]=[CH:20][C:9]([C:2]3([OH:1])[CH2:7][CH2:6][CH:5]([N:21]4[CH2:24][CH:23]([NH:25][C:26]([CH2:28][NH:29][C:30](=[O:41])[C:31]5[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:38])[F:39])[CH:32]=5)=[O:27])[CH2:22]4)[CH2:4][CH2:3]3)=[CH:10][C:11]=2[N:15]([CH3:16])[C:14]1=[O:17]

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541919HCID 59541919, compound

Product 1

HCID 49763095HCID 49763095, compound

Procedure

The title compound was prepared as a white solid by reductive amination of 5-(1-hydroxy-4-oxo-cyclohexyl)-1,3-dimethyl-1,3-dihydro-benzoimidazol-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.

Sources & evidence

ORD record
ord-cb317e96e57c41cc9127a8dec7328ed0
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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