N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49763098, compound

HRID 1893298Notes

Reaction equation

HRID 1893298 reaction equation
[CH2:1]([N:3]1[C:7]2[CH:8]=[C:9]([C:12]3([OH:19])[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]3)[CH:10]=[CH:11][C:6]=2[O:5][C:4]1=[O:20])[CH3:2].[NH:21]1[CH2:24][CH:23]([NH:25][C:26]([CH2:28][NH:29][C:30](=[O:41])[C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:39])[F:38])[CH:32]=2)=[O:27])[CH2:22]1>>[CH2:1]([N:3]1[C:7]2[CH:8]=[C:9]([C:12]3([OH:19])[CH2:17][CH2:16][CH:15]([N:21]4[CH2:24][CH:23]([NH:25][C:26]([CH2:28][NH:29][C:30](=[O:41])[C:31]5[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:38])[F:39])[CH:32]=5)=[O:27])[CH2:22]4)[CH2:14][CH2:13]3)[CH:10]=[CH:11][C:6]=2[O:5][C:4]1=[O:20])[CH3:2]

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541917HCID 59541917, compound

Product 1

HCID 49763098HCID 49763098, compound

Procedure

The title compound was prepared as a white solid by reductive amination of 3-ethyl-5-(1-hydroxy-4-oxo-cyclohexyl)-3H-benzooxazol-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4.

Sources & evidence

ORD record
ord-09e138f0c7a74d4e8f931f6204ce38b5
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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