HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → {[1-(4-Phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | (4-Phenyl-cyclohexyl)-azetidin-3-ylamine TFA Salt | HCID 86646680 | — |
| Product | {[1-(4-Phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-carbamic acid tert-butyl ester | HCID 59541886 | — |
Reaction Steps
The title compound was prepared as a white solid from the EDCI coupling of (4-phenyl-cyclohexyl)-azetidin-3-ylamine TFA salt (as prepared in the previous step) and tert-butoxycarbonylamino-acetic acid (Aldrich) using the procedure described in Step F of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513229B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-844e9dea20684b7286f25156050ebac7 |
| Source note | uspto-grants-2013_08 |