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1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | 2-Fluoro-5-(trifluoromethyl)benzoic acid | HCID 688292 | — |
| 反応物 | 2-Amino-N-[1-(4-phenyl-cyclohexyl)-azetidin-3-yl]-acetamide TFA salt | HCID 86646681 | — |
| 生成物 | 2-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide | HCID 49763099 | — |
反応手順
The title compound was prepared as a white solid from the EDCI coupling of 2-amino-N-[1-(4-phenyl-cyclohexyl)-azetidin-3-yl]-acetamide TFA salt (as prepared in the previous step) and 2-fluoro-5-trifluoromethyl-benzoic acid (Aldrich) using the procedure described in Step F of Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08513229B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-6c83105e7cb7457ba5952707c724e6a5 |
| 出典メモ | uspto-grants-2013_08 |