tert-Butyl isocyanate → HCID 49763573, compound

HRID 1893322Notes

Reaction equation

HRID 1893322 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[C:5]([NH:7][CH2:8][C:9](=[O:27])[NH:10][CH:11]1[CH2:14][N:13]([CH:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[CH2:12]1)=[O:6].[C:35]([N:39]=[C:40]=[O:41])([CH3:38])([CH3:37])[CH3:36]>>[C:35]([NH:39][C:40](=[O:41])[NH:1][C:2]1[CH:3]=[C:4]([CH:28]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:30]=1)[C:5]([NH:7][CH2:8][C:9](=[O:27])[NH:10][CH:11]1[CH2:14][N:13]([CH:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:17][CH2:16]2)[CH2:12]1)=[O:6])([CH3:38])([CH3:37])[CH3:36]

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 49763457HCID 49763457, compound

Product 1

HCID 49763573HCID 49763573, compound

Procedure

The title compound was prepared as a white solid from coupling of 3-amino-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide (as prepared in Example 79) with t-butyl-isocyanate (Aldrich) using the procedure described in Example 18.

Sources & evidence

ORD record
ord-9dc0a7ceec4a4488848c9978ce147d01
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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