N-(1,4-dioxaspiro[4.5]dec-8-ylidene)-2-methylpropane-2-sulfinamide → HCID 59541941, compound

HRID 1893328Notes

Reaction equation

HRID 1893328 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([Mg]Br)=[CH:5][CH:4]=1.[O:11]1[C:15]2([CH2:20][CH2:19][C:18](=[N:21]S(C(C)(C)C)=O)[CH2:17][CH2:16]2)OCC1>>[NH2:21][C:18]1([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:19][CH2:20][C:15](=[O:11])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 59733754N-(1,4-dioxaspiro[4.5]dec-8-ylidene)-2-methylpropane-2-sulfinamideHCID 178491912HCID 178491912, compound

Product 1

HCID 59541941HCID 59541941, compound

Procedure

The title compound was prepared as a white solid from addition of 4-methoxy-phenyl magnesium bromide (Aldrich) to 2-methyl-propane-2-sulfinic acid (1,4-dioxa-spiro[4.5]dec-8-ylidene)-amide (as prepared in Example 84, Step A) followed by the hydrolysis using the procedure described in Step B of Example 84.

Sources & evidence

ORD record
ord-d5779e24c1f24286b4e941dbdfbe4f8d
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

Loading…