Hydrochloric Acid → HCID 178525744, compound

Participants

Reaction Steps

A solution of trans-4-pyrazol-1-yl-cyclohexanecarboxylic acid ethyl ester (95 mg, 0.43 mmol) in 1,4-dioxane (4.3 ml) and 2 M aqueous sodium hydroxide solution (2.2 ml, 4.4 mmol) was stirred at room temperature for 20 h. The pH was adjusted to 2 by addition of 2 M aqueous hydrochloric acid. The mixture was partitioned between ethyl acetate (25 ml) and water (25 ml). The layers were separated. The aqueous layer was extracted with two 25-ml portions of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound (80 mg, 96%) as light brown solid. MS m/e: 193 ([M−H]−)

Provenance & Evidence