Hydrochloric Acid → HCID 178434086, compound

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Reaction Steps

A solution of trans-4-(3,4,5-trimethyl-pyrazol-1-yl)-cyclohexanecarboxylic acid ethyl ester (180 mg, 0.681 mmol) in 1,4-dioxane (6.8 ml) and 2 M aqueous sodium hydroxide solution (3.4 ml, 6.8 mmol) was stirred at room temperature for 3 days. The pH was adjusted to 3 by addition of 2 M aqueous hydrochloric acid. The mixture was partitioned between ethyl acetate (25 ml) and water (25 ml). The layers were separated. The aqueous layer was extracted with two 25-ml portions of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound (141 mg, 88%) as light brown solid. MS m/e: 235 ([M−H]−)

Provenance & Evidence