1229186-69-9 → HCID 66884089, compound

HRID 1893396Notes

Reaction equation

HRID 1893396 reaction equation
[Br:1][C:2]1[C:3]([O:9][C@@H:10]2[CH2:14][CH2:13][O:12][CH2:11]2)=[N:4][C:5](Cl)=[N:6][CH:7]=1.Cl.[NH2:16][CH:17]1[CH2:22][CH2:21][C:20]([CH3:24])([OH:23])[CH2:19][CH2:18]1>>[O:12]1[CH2:13][CH2:14][C@@H:10]([O:9][C:3]2[C:2]([Br:1])=[CH:7][N:6]=[C:5]([NH:16][CH:17]3[CH2:22][CH2:21][C:20]([CH3:24])([OH:23])[CH2:19][CH2:18]3)[N:4]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 218771341229186-69-9HCID 58515275HCID 58515275, compound

Product 1

HCID 66884089HCID 66884089, compound

Procedure

Using the procedure of Example 78, Step 2, (R)-5-bromo-2-chloro-4-(tetrahydrofuran-3-yloxy)pyrimidine was reacted with 4-amino-1-methylcyclohexanol HCl salt to provide the title compound. MS (ESI) m/z: Found: 372 (M++1), Calc. 371 (M+).

Sources & evidence

ORD record
ord-4f78bd80ad1841af85dea98aff5919ca
Source dataset
uspto-grants-2013_08
Patent number
US08513242B2

Reaction notes

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