2-(Trifluoromethyl)imidazo[1,2-a]pyrazine → 2-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine

Participants

Reaction Steps

2-(Trifluoromethyl)imidazo[1,2-a]pyrazine (1.63 g, 8.71 mmol) was dissolved in methanol (70 mL) and hydrogenated at RT under 1 atm hydrogen over 10% palladium on carbon paste (0.464 g, 0.436 mmol) for 16 h. The catalyst was filtered and the filtrate concentrated to an oil that solidified upon standing to a waxy solid 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1.56 g, 8.16 mmol, 94% yield).

Provenance & Evidence