Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 2-methyl-5H,6H,7H,8H-imidazo(1,2-a)pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Chloroacetone | HCID 6571 | — |
| 반응물 | 2-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine | HCID 14719928 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-methyl-5H,6H,7H,8H-imidazo(1,2-a)pyrazine | HCID 14719924 | — |
반응 단계
2-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine was prepared in an analogous manner to that described above for 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (Intermediate 4) but starting from 1-chloro-2-propanone instead of 3-bromo-1,1,1-trifluoro-2-propanone and using platinum (IV) oxide and ethanol in the place of 10% palladium on carbon paste and methanol for the hydrogenation step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08513248B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-101a81792ae74a6e94f9801f7e91a112 |
| 출처 메모 | uspto-grants-2013_08 |