N-bromobutanimide → HCID 66599141, compound

Participants

Reaction Conditions

Reaction Steps

7-[(2-Chloro-4-fluorophenyl)carbonyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (I21) (300 mg, 1.073 mmol) was dissolved in N,N-dimethylformamide (DMF) (2 mL) and treated with NBS (200 mg, 1.126 mmol). The solution was stirred at 25° C. for 16 h. The solvents were removed in vacuo and the residue purified by MDAP (High pH method) to afford desired product in 210 mg.

Provenance & Evidence