Sodium borohydride → HCID 59333317, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the 4-[(3-hydroxypropyl)amino]-7-(trifluoromethyl)imidazo[1,2-a]quinoxaline-1-carbaldehyde prepared as in example 36 (8 mg, 0.024 mmol) in anhydrous methanol (300 μL), cooled at 0° C. was added sodium borohydride (2 mg, 0.047 mmol). The mixture was allowed to warm to room temperature over 1 h under argon and then diluted with water and extracted three times with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered and evaporated. The crude product was purified by preparative TLC (silica gel, dichloromethane/methanol 9/1) to afford the title compound as a white solid (5 mg, 61%).

Provenance & Evidence