Benzylamine → HCID 25120534, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the benzylamine (13 μL, 0.12 mmol) in methanol (400 μL) was added 4-[(3-hydroxypropyl)amino]-7-(trifluoromethyl)imidazo[1,2-a]quinoxaline-1-carbaldehyde (35 mg, 0.10 mmol). The reaction mixture was stirred at 30° C. for 17 h. After addition of NaBH4 (5 mg, 0.12 mmol), the mixture was stirred at 30° C. for 5 h. Then it was concentrated, diluted in ethyl acetate, washed with an aqueous saturated solution of ammonium chloride and extracted with ethyl acetate. The combined organic phases were dried over Na2SO4, filtered, concentrated in vacuo to give, after purification by preparative TLC (dichloromethane/methanol 9/1), the title compound (32 mg, 75%) as a colorless oil.

Provenance & Evidence